Anti-cancer NKT Immune cell therapy
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What is Natural Killer T Cell?
Immune cells have both the characteristics of T cells, which are acquired immune cells, and natural killer cells, which are innate immune cells.
NKT cell(Natural killer T cell) is the fourth lymphocyte discovered in 1986 by Dr. Masaru Taniguchi (currently a special advisor to the Institute of Physical and Chemical Research (RIKEN). The American Society of Immunology recognized the discovery of these iNTK cells as "Pillars of Immunology."
The first discoverer, Dr. Masaru Taniguchi, is currently an advisory member of Shangrila Bio and communicates through regular videotelephony.
About Anti-cancer NKT Immune cell therapy
It is an innovative treatment that overcomes the side effects such as partial loss of the body and destruction of normal cells by typical chemotherapy (surgery, radiation therapy, and chemotherapy) and the limitations of conventional immune cell therapy that cannot remove mutated cancer cells. It can be applied to all types of cancer by activating the patient's immune system without having to do so.
NKT cell therapy is a treatment that activates and rapidly grows immune cells that attack cancer, creating a long-term immune memory for cancer and creating a fundamental system that can continuously attack cancer. Through this, it can be simultaneously removed 'cells expressing cancer antigen', 'cells not expressing cancer antigen', and newly emerging 'mutant cancer cell'. This latest treatment aims to develop to prevent the progression, recurrence, and metastasis of cancer.
In NKT cell therapy, the patient's blood is collected, and monocyte cells are extracted through a component blood sampling process. Here, dendritic cells and glycolipids (a-GalCer) are added, cultured, and then injected back into the patient's body through a vein. Subsequently, when NKT cells are activated, they produce a large amount of interferon-gamma (IFN-r), and it proliferates, promotes, and activates both NK cells of the natural immune system and killer T cells of the acquired immune system (adjuvant action) to exert an anti-cancer effect.
Anti-cancer NKT Immune cell therapy is currently (as of September 2021), being performed only at Japanese clinics approved by the Institute of Physical and Chemical Research (RIKEN), which discovered NKT cells for the first time. Through an agreement in 2020 with the company AMBICION of Japan, which holds the patent rights, we have the exclusive right in Korea for the NKT cell therapy patent license.
Characteristics of Anti-cancer NKT Immune cell therapy
Curable for any cancer
Unlike typical treatments that target cancer cells, it is a treatment that activates ‘immunocytes’ that remove cancers from the patient’s own body, so it can be effective against any type of cancer (pancreatic cancer, lung cancer, etc.).
Long-term immunological memory
Existing T-cell and NK cell therapy had to be administered every two weeks because the survival period in the body was up to two weeks. But NKT cell therapy is a cell that forms a long-term immunological memory for cancer, and it continuously attacks cancer for up to one year only by administering it twice a year (one month apart).
Simultaneous removal of mutant cancer cells
Because it can activate both the natural and acquired immune systems at the same time, it is a treatment that simultaneously removes all of the ‘cancer antigen-expressing cells’, ‘cells that do not express cancer antigens’ and ‘mutant cancer cells’, which are exist in any type of cancer. Therefore, it can be expected to have the effect of inhibiting cancer progression, recurrence, and metastasis.
Anyone can treat
The antigen receptor of NKT cells is common to all people, and the NKT ligand that activates NKT cells binds to only one dependent CD1d molecule and activates NKT, so anyone can expect an effect regardless of the histocompatibility antigen (HLA type).
Recovery of immunodeficiency due to cancer
Immune cells receive antigen information from cancer cells from mature dendritic cells and attack cancer. However, a person with cancer has a lack of immunity due to immature dendritic cells that do not present antigen information because the differentiation of dendritic cells is suppressed by the immunosuppressive substances emitted by cancer cells in the body. NKT cells can activate the immune system cells of cancer patients and restore the patient's immunity to cancer.
Make up for side effects of existing chemotherapy
It is a treatment method through the activation of immune cells existing in the body, there are no side effects that conventional chemotherapy has.
The safety and effectiveness of the antitumor effect of NKT cells have been confirmed through clinical studies, such as chemical resistance, impossibility, and radiation resistance progression in solid cancer patients, and has already been approved as an Advanced Medical Care B program by the Japanese government. In addition, Chiba University, Keio University, and Tokyo University have already shown excellent treatment results in Japan.
NKT Cell therapy Process
Patient treatment Process
Cell therapy product production process
